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Through secondary AMPK activation and suppression of SREBP-1cdependent lipogenesis, GLP-1 RAs reduce hepatic de novo lipogenesis and gluconeogenic enzyme expression while improving glycogen storage [78]
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In addition, a variety of synthetic compounds with in vitro antioxidant activity have been developed to treat diseases, including recombinant SOD, catalase, nitroxyl radicals, iron ion chelators, deuterated PUFAs, thiols, and ROS-generating enzyme inhibitors
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